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Article

A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.

The Journal of biological chemistry - 18 Feb 2000

Cheng Y Q, Walton J D

Abstract excerpt

The cyclic tetrapeptide HC-toxin is an essential virulence determinant for the plant pathogenic fungus Cochliobolus carbonum and an inhibitor of histone deacetylase. The major form of HC-toxin contains the D-isomers of Ala and Pro. The non-ribosomal peptide synthetase that synthesizes HC-toxin has only one epimerizing domain for conversion of L-Pro to D-Pro; the source of D-Ala has remained unknown. Here we...

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Identifiers

PMID: 10671527
DOI: 10.1074/jbc.275.7.4906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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