Regulation of cyclic peptide biosynthesis and pathogenicity in Cochliobolus carbonum by TOXEp, a novel protein with a bZIP basic DNA-binding motif and four ankyrin repeats.

Abstract excerpt

HC-toxin is an epoxide-containing cyclic tetrapeptide that is a critical virulence determinant in the pathogenic interaction between the filamentous fungus Cochliobolus carbonum and maize. HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase. The...

Topics

• Amino Acid Sequence
• Ankyrins
• Ascomycota
• Base Sequence
• Binding Sites
• Carrier Proteins
• Chromosome Mapping
• DNA-Binding Proteins
• Fungal Proteins
• Membrane Transport Proteins
• Molecular Sequence Data
• Mutation
• Peptides, Cyclic
• Repetitive Sequences, Amino Acid
• Sequence Analysis