Article
The Proposed Neurotoxin β-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the Cyanobacterium Anabaena PCC 7120.
Toxins - 13 Aug 2020
Wang Zi-Qian, Wang Suqin, Zhang Ju-Yuan, Lin Gui-Ming, Gan Nanqin, Song Lirong, Zeng Xiaoli, Zhang Cheng-Cai
Abstract excerpt
Produced by cyanobacteria and some plants, BMAA is considered as an important environmental factor in the occurrence of some neurodegenerative diseases. Neither the underlying mechanism of its toxicity, nor its biosynthetic or metabolic pathway in cyanobacteria is understood. Interestingly, BMAA is found to be toxic to some cyanobacteria, making it possible to dissect the mechanism of BMAA metabolism by genetic...
Topics
- Amino Acid Transport Systems
- Amino Acids
- Amino Acids, Diamino
- Anabaena
- Cyanobacteria Toxins
- Genome, Bacterial
- Mutation
- Neurotoxins