Article
Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae.
Nature communications - 8 Mar 2021
Will Robert C, Ramamurthy Thandavarayan, Sharma Naresh Chand, Veeraraghavan Balaji, Sangal Lucky, Haldar Pradeep, Pragasam Agila Kumari, Vasudevan Karthick, Kumar Dhirendra, Das Bhabatosh, Heinz Eva, Melnikov Vyacheslav, Baker Stephen, Sangal Vartul, Dougan Gordon, Mutreja Ankur
Abstract excerpt
Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine...
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