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Osteoblast-derived TGF?-1 modulates matrix degrading protease expression and activity in prostate cancer cells

15 Jun 2000

Abstract excerpt

Tumor progression and metastasis may result in part from the selection of cell clones competent for survival, invasion and growth at secondary sites and characterized by loss of growth inhibitory responses, acquisition of increased adhesiveness and enhanced motility and protease expression. Transforming growth factor-beta1 (TGF-beta1) is produced by osteoblasts (OB) in a latent form and is activated by proteases...

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PMID: 10652434
DOI: 10.1002/(sici)1097-0215(20000615)86:6<888::aid-ijc21>3.0.co;2-7

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