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Article

Biochemistry and neuropathology of mice doubly deficient in synthesis and degradation of galactosylceramide.

Journal of neuroscience research - 15 Jan 2000

Ezoe T, Vanier M T, Oya Y, Popko B, Tohyama J, Matsuda J, Suzuki K, Suzuki K

Abstract excerpt

We have generated mice doubly deficient in both synthesis and degradation of galactosylceramide by cross-breeding twitcher mice and galactosylceramide synthase (UDP-galactose:ceramide galactosyltransferase, CGT) knockout mice. The prediction that the phenotype of the doubly deficient mice should be the same as the cgt -/- mice, since the degrading enzyme should not be necessary if the substrate is not...

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Identifiers

PMID: 10650875
DOI: 10.1002/(sici)1097-4547(20000115)59:2<170::aid-jnr3>3.0.co;2-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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