Article
APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis.
British journal of cancer - 1 Jan 2000
Ficari F, Cama A, Valanzano R, Curia M C, Palmirotta R, Aceto G, Esposito D L, Crognale S, Lombardi A, Messerini L, Mariani-Costantini R, Tonelli F, Battista P
Abstract excerpt
Correlations between germline APC mutation sites and colorectal pathophenotypes, as evaluated by the direct count of adenomas at colectomy, were investigated analysing colectomy specimens from 29 FAP patients carrying one mis-sense (codon 208) and 14 frame-shift or non-sense APC mutations (codons 232, 367, 437, 623, 876, 995, 1061, 1068, 1075, 1112, 1114, 1309, 1324, 1556). The mis-sense mutation at codon 208 was...
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