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Article

Molecular pathology of thymomas: implications for diagnosis and therapy.

Virchows Archiv : an international journal of pathology - 1 Jan 2021

Marx Alexander, Belharazem Djeda, Lee De-Hyung, Popovic Zoran V, Reißfelder Christoph, Schalke Berthold, Schölch Sebastian, Ströbel Philipp, Weis Cleo-Aron, Yamada Yosuke

Abstract excerpt

Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in relation to GTF2I...

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Source

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Identifiers

PMID: 33674910
DOI: 10.1007/s00428-021-03068-8
PMCID: PMC7966134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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