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Article

An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning.

The Journal of biological chemistry - 28 Jan 2000

Jaffe E K, Volin M, Bronson-Mullins C R, Dunbrack R L, Kervinen J, Martins J, Quinlan J F, Sazinsky M H, Steinhouse E M, Yeung A T

Abstract excerpt

Porphobilinogen synthase (PBGS) is an ancient enzyme essential to tetrapyrrole biosynthesis (e.g. heme, chlorophyll, and vitamin B(12)). Two common alleles encoding human PBGS, K59 and N59, have been correlated with differential susceptibility of humans to lead poisoning. However, a model for human PBGS based on homologous crystal structures shows the location of the allelic variation to be distant from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10644722
DOI: 10.1074/jbc.275.4.2619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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