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Article

Crystal structure of human uroporphyrinogen III synthase.

The EMBO journal - 1 Nov 2001

Mathews M A, Schubert H L, Whitby F G, Alexander K J, Schadick K, Bergonia H A, Phillips J D, Hill C P

Abstract excerpt

Uroporphyrinogen III synthase, U3S, the fourth enzyme in the porphyrin biosynthetic pathway, catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrino gen III, which is used in several different pathways to form heme, siroheme, chlorophyll, F(430) and vitamin B(12). U3S activity is essential in all organisms, and decreased activity in humans leads to the autosomal...

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Identifiers

PMID: 11689424
DOI: 10.1093/emboj/20.21.5832
PMCID: PMC125291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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