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Article

An unusual phylogenetic variation in the metal ion binding sites of porphobilinogen synthase.

Chemistry & biology - 1 Jan 2003

Jaffe Eileen K

Abstract excerpt

Porphobilinogen synthase (PBGS), which catalyzes the first common step in tetrapyrrole biosynthesis, contains a unique phylogenetic variation in the use of metal ions. Using sequence, structure, and enzymological information, this work codifies the phylogenetic segregation of metal utilization in PBGS from archaea, bacteria, and eucarya. All PBGS contain an active site metal binding sequence, determined herein to...

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PMID: 12573695
DOI: 10.1016/s1074-5521(02)00296-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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