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Article

Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins).

The Journal of biological chemistry - 10 Mar 2006

Tang Lei, Breinig Sabine, Stith Linda, Mischel Adele, Tannir Justin, Kokona Bashkim, Fairman Robert, Jaffe Eileen K

Abstract excerpt

Porphobilinogen synthase (PBGS) is an obligate oligomer that can exist in functionally distinct quaternary states of different stoichiometries, which are called morpheeins. The morpheein concept describes an ensemble of quaternary structure isoforms wherein different structures of the monomer dictate different multiplicities of the oligomer (Jaffe, E. K. (2005) Trends Biochem. Sci. 30, 490-497). Human PBGS...

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PMID: 16377642
DOI: 10.1074/jbc.M511134200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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