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Article

The alpha-toxin of Clostridium septicum is essential for virulence.

Molecular microbiology - 1 Sept 2005

Kennedy Catherine L, Krejany Efrosinia O, Young Lauren F, O'Connor Jennifer R, Awad Milena M, Boyd Richard L, Emmins John J, Lyras Dena, Rood Julian I

Abstract excerpt

Clostridium septicum is the causative agent of spontaneous gas gangrene or atraumatic myonecrosis, a sudden and frequently fatal infection that is increasingly associated with malignancy of the colon. Little is known about the disease process although the focus of virulence studies has been the alpha-toxin, a pore-forming cytolysin that is encoded by the csa gene and secreted as an inactive protoxin. Until now a...

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PMID: 16102005
DOI: 10.1111/j.1365-2958.2005.04774.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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