Article
Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment.
Mutation research - 17 Dec 1999
Dennog C, Gedik C, Wood S, Speit G
Abstract excerpt
DNA damage induced by reactive oxygen species (ROS) seems to play an important role in the induction of mutations and cancer. We have recently shown that hyperbaric oxygen (HBO) treatment of volunteers (i.e., exposure to 100% oxygen at a pressure of 2.5 ATA) induces DNA damage detected in leukocytes with the comet assay. Using formamidopyrimidine-DNA glycosylase (FPG protein) we provided indirect evidence for the...
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