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Article

Structural abnormalities in the G-CSF receptor in severe congenital neutropenia.

Journal of hematotherapy & stem cell research - 1 Aug 1999

Deshpande R V, Lalezari P, Pergolizzi R G, Moore M A

Abstract excerpt

Structural abnormalities in the cytoplasmic region of the G-CSF receptor (G-CSF-R) or defects in signal transduction pathways triggered by the G-CSF-R or both have been implicated in the development of neutropenia and increased prediposition to leukemia in patients with severe congenital neutropenia (SCN). To assess the structural integrity of the G-CSF-R in SCN patients, the transmembrane and cytoplasmic regions...

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Identifiers

PMID: 10634179
DOI: 10.1089/152581699320171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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