Article
Studies on the role of human insulin-like growth factor-II (IGF-II)-dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease-resistant IGFBP-4 analogs.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1999
Qin X, Byun D, Strong D D, Baylink D J, Mohan S
Abstract excerpt
To characterize the insulin-like growth factor binding protein-4 (IGFBP-4) protease produced by human osteoblasts (hOBs), we localized and determined the role of the proteolytic domains in human IGFBP-4 (hIGFBP-4) in modulating IGF-II actions. N-terminal amino acid sequence and mass spectrometric analyses of the 6xHis-tagged IGFBP-4 proteolytic fragments revealed that Met135-Lys136 was the only cleavage site...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.