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Article

Participation of Bcl-2/Bax-alpha in glutamate-induced apoptosis of human glioblastoma cells.

Journal of neuro-oncology - 1 Sept 1999

Nishi T, Takahashi M, Ito H, Yoshihama I, Takada E, Mizuguchi J

Abstract excerpt

Glutamate has been shown to function as a toxic agent in neuronal and glial cells, as well as an excitatory neurotransmitter throughout the central nervous system. In the present study, we examined the effect of increasing glutamate concentration on the induction of apoptosis in the two human glioblastoma cell lines GB-4 and GB-12. Glutamate exposure caused cell death of GB-4 and GB-12 in a dose-dependent manner....

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Source

Identifiers

PMID: 10619494
DOI: 10.1023/a:1006310815374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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