Article
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase.
Science (New York, N.Y.) - 24 Dec 1999
Estévez A G, Crow J P, Sampson J B, Reiter C, Zhuang Y, Richardson G J, Tarpey M M, Barbeito L, Beckman J S
Abstract excerpt
Mutations in copper, zinc superoxide dismutase (SOD) have been implicated in the selective death of motor neurons in 2 percent of amyotrophic lateral sclerosis (ALS) patients. The loss of zinc from either wild-type or ALS-mutant SODs was sufficient to induce apoptosis in cultured motor neurons. Toxicity required that copper be bound to SOD and depended on endogenous production of nitric oxide. When replete with...
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