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Article

Hydrogen peroxide damages the zinc-binding site of zinc-deficient Cu,Zn superoxide dismutase.

Archives of biochemistry and biophysics - 1 Aug 2001

Sampson J B, Beckman J S

Abstract excerpt

Mutations in Cu,Zn superoxide dismutase (Cu,Zn SOD) account for approximately 20% of cases of familial amyotrophic lateral sclerosis (ALS), a late-onset neurodegenerative disease affecting motor neurons. These mutations decrease protein stability and lower zinc affinity. Zinc-deficient SOD (Cu,E SOD) has altered redox activities and is toxic to motor neurons in vitro. Using bovine SOD, we studied the effects of...

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Identifiers

PMID: 11469788
DOI: 10.1006/abbi.2001.2418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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