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Article

Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis.

Molecular and cellular biology - 1 Jan 2000

Whitman S, Wang X, Shalaby R, Shtivelman E

Abstract excerpt

The human gene CC3 is a metastasis suppressor for small cell lung carcinoma (SCLC) in vivo. The ability of CC3 to impair the apoptotic resistance of tumor cells is likely to contribute to metastasis suppression. We describe here an alternatively spliced RNA of CC3, designated TC3, that encodes an unstable protein with antiapoptotic activity. TC3 and CC3 proteins share amino-terminal sequences, but TC3 has a...

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Identifiers

PMID: 10611237
DOI: 10.1128/MCB.20.2.583-593.2000
PMCID: PMC85138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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