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Article

Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).

European journal of human genetics : EJHG - 1 Dec 1999

Veldhuisen B, Spruit L, Dauwerse H G, Breuning M H, Peters D J

Abstract excerpt

Autosomal Dominant Polycystic Kidney Disease (ADPKD), a common inherited disease leading to progressive renal failure, can be caused by a mutation in either the PKD1 or PKD2 gene. Both genes encode for putative transmembrane proteins, polycystin-1 and polycystin-2, which show significant homology to each other and are believed to interact at their carboxy termini. To identify genes that code for related proteins...

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Source

Identifiers

PMID: 10602361
DOI: 10.1038/sj.ejhg.5200383

Genes

PKD1
PKD2
PKDREJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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