Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 1999

Lee K S, Song S, Erikson R L

Abstract excerpt

Members of the polo subfamily of protein kinases play pivotal roles in cell-cycle control and proliferation. In addition to a high degree of sequence similarity in the kinase domain, polo kinases contain a strikingly conserved motif termed "polo-box" in the noncatalytic C-terminal domain. We have previously shown that the mammalian polo-like kinase Plk is a functional homolog of Saccharomyces cerevisiae Cdc5....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Cell Cycle Proteins

Share to Drosophila Proteins

Share to Protein Serine-Threonine Kinases

Share to RNA-Binding Proteins

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10588710
DOI: 10.1073/pnas.96.25.14360
PMCID: PMC24441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae.PMID 10588710Read ↗

Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.Semantic proximity Read ↗

A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis.Semantic proximity Read ↗

Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.Semantic proximity Read ↗

Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase.Semantic proximity Read ↗

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.Semantic proximity Read ↗

Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.Semantic proximity Read ↗

Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.Semantic proximity Read ↗

Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p.Semantic proximity Read ↗

Polo-like kinase-activating kinasesSemantic proximity Read ↗

Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.Semantic proximity Read ↗

A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.Semantic proximity Read ↗

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.