Article
Selection of microbial mutants tolerant to extreme environmental stress using continuous culture-control design.
Biotechnology progress - 1 Jan 2000
Lane P G, Hutter A, Oliver S G, Butler P R
Abstract excerpt
The design of controllers for a continuous selection technique (BOICS; Brown and Oliver, 1982) is considered. This technique is used to obtain microbial mutants that are tolerant to extreme environmental stress. Applications of BOICS have been hampered by the problem of controller design. In this paper, a modified implementation of BOICS is considered which has a number of practical advantages. A model-based...
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