Analysis of a continuous-culture technique for the selection of mutants tolerant to extreme environmental stress.

doi:10.1002/(sici)1097-0290(19991120)65:4<397::aid-bit4>3.0.co;2-x

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Analysis of a continuous-culture technique for the selection of mutants tolerant to extreme environmental stress.

Biotechnology and bioengineering - 20 Nov 1999

Lane P G, Oliver S G, Butler P R

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An analysis is presented of a continuous-culture technique named "Brown and Oliver Interactive-Continuous Selection" (BOICS; Brown and Oliver, 1982), that was devised for the selection of microbial mutants tolerant to extreme environmental stress. The case in which the stress is due to a growth inhibitor is considered. The possible steady outcomes of competition between mutants in BOICS are analyzed under the...

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Analysis of a continuous-culture technique for the selection of mutants tolerant to extreme environmental stress.

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