Article
Yeast prions: bungee cord domains' balancing act.
Current biology : CB - 18 Nov 1999
Lansbury P T
Abstract excerpt
The yeast prion-like protein Sup35 has repeats responsible for the reversible induction of an altered, but advantageous phenotype. The expansion of similar repeat domains in several mammalian proteins is associated with neurodegenerative disease - so why are these 'bungee cord' domains conserved?
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