Article
[Frequency of the APOE-4 allele in Alzheimer's disease and its variation with age in Asturias (Spain)].
Medicina clinica - 16 Oct 1999
Alvarez V, Alvarez R, Peña J, Lahoz C H, Martínez C, Menéndez-Guisasola L, Salas-Puig J, Morís G, Uría D, Menes B B, Ribacoba R, Vidal J A, Coto E
Abstract excerpt
BACKGROUND: Patients with late-onset Alzheimer's disease show a higher frequency of the APOE-4 than controls. The usefulness of the APOE genotyping in the diagnosis of the disease is controversial. Recently, an age dependent prevalence of APOE-4 in Alzheimer's disease has been described, with a maximum frequency for patients with an age at onset between 65 and 80 years. Additionally, the APOE-4 frequency in...
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