Article
MICA gene polymorphism and the risk to develop cervical intraepithelial neoplasia.
Human immunology - 1 Oct 1999
Ghaderi M, Hjelmström P, Hallmans G, Wiklund F, Lenner P, Dillner J, Sanjeevi C B
Abstract excerpt
Cervical intraepithelial neoplasia (CIN) is associated with human papillomaviruses (HPV) and the HLA genes. The MICA (MHC class I chain-related gene A) is expressed by keratinocytes and epithelial cells and interacts with gamma delta T cells. It is therefore possible that MICA might influence the pathogenesis of CIN and cervical cancer through presentation of viral or tumor antigens. To investigate this, we...
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