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Article

Early changes in costameric and mitochondrial protein expression with unloading are muscle specific.

BioMed research international - 1 Jan 2014

Flück Martin, Li Ruowei, Valdivieso Paola, Linnehan Richard M, Castells Josiane, Tesch Per, Gustafsson Thomas

Abstract excerpt

We hypothesised that load-sensitive expression of costameric proteins, which hold the sarcomere in place and position the mitochondria, contributes to the early adaptations of antigravity muscle to unloading and would depend on muscle fibre composition and chymotrypsin activity of the proteasome. Biopsies were obtained from vastus lateralis (VL) and soleus (SOL) muscles of eight men before and after 3 days of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25313365
DOI: 10.1155/2014/519310
PMCID: PMC4182083

Genes

UCP3
NDUFA9
SDHA
UQCRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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