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Article

Different effects of 3-week disuse on phenotype and gene expression in calf and thigh muscles.

The Journal of physiology - 1 Jun 2026

Orlova Mira A, Kurochkina Nadia S, Zhedyaev Roman Yu, Vavilov Nikita E, Zgoda Viktor G, Puchkova Alina A, Borzykh Anna A, Vepkhvadze Tatiana F, Lednev Egor M, Makhnovskii Pavel A, Galkin Gleb V, Novikov Valery E, Shpakov Alexey V, Popov Daniil V

Abstract excerpt

Disuse, like several other pathological conditions, has specific effects on various skeletal muscles; the mechanisms underlying these responses remain unclear. We aimed to compare the disuse-induced changes in the phenotype and proteome of the calf and thigh muscles, and to assess the extent to which these proteomic changes are regulated at the mRNA and other levels. Twelve healthy young males participated in a...

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PMID: 42113967
DOI: 10.1113/JP290722

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