Article
Genotyping of the CCR5 chemokine receptor by isothermal NASBA amplification and differential probe hybridization.
Clinical and diagnostic laboratory immunology - 1 Nov 1999
Romano J W, Tetali S, Lee E M, Shurtliff R N, Wang X P, Pahwa S, Kaplan M H, Ginocchio C C
Abstract excerpt
The human CCR5 chemokine receptor functions as a coreceptor with CD4 for infection by macrophage-tropic isolates of human immunodeficiency virus type 1 (HIV-1). A mutated CCR5 allele which encodes a protein that does not function as a coreceptor for HIV-1 has been identified. Thus, expression of the wild-type and/or mutation allele is relevant to determining the infectability of patient peripheral blood...
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