Article
[Frequency of the mutated allele of CCR-5 receptor in HIV-1 positive and negative individuals in the Province of Chaco].
Medicina - 1 Jan 2000
Motta P, Cibulsky L, Iliovich E, Habegger de Sorrentino A
Abstract excerpt
The importance of chemokine receptors in the pathophysiology of HIV infection became apparent when it was demonstrated that persons at high risk for HIV-1 infection remain uninfected when they carry a polymorphic variant of CCR5. In individuals who are homozygous for the 32 base-pair deletion in the CCR5 gene, a functional protein cannot be synthesized and such persons are not found in HIV-1 positive cohorts....
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