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Article

Ku is associated with the telomere in mammals

26 Oct 1999

Abstract excerpt

Telomeres are specialized DNA/protein complexes that comprise the ends of eukaryotic chromosomes. The highly expressed Ku heterodimer, composed of 70 and 80 K(d) subunits (Ku70 and Ku80), is the high-affinity DNA binding component of the DNA-dependent protein kinase. Ku is critical for nonhomologous DNA double-stranded break repair and site-specific recombination of V(D)J gene segments. Ku also plays an important...

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Identifiers

PMID: 10535943
DOI: 10.1073/pnas.96.22.12454

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