Article
The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles.
Transplantation - 15 Oct 1999
Prasad V K, Heller G, Kernan N A, O'Reilly R J, Yang S Y
Abstract excerpt
BACKGROUND: Recent evidence suggests a more significant role of HLA-C as a target of alloreactions after bone marrow transplantation than previously suspected. Although linkage disequilibrium (LD) between HLA-B and -C serogroups is well documented, the level of LD at the allelic level is not know...
Topics
- Alleles
- Bone Marrow Transplantation
- DNA
- Gene Frequency
- HLA-B Antigens
- HLA-C Antigens
- Haplotypes
- Histocompatibility Testing
- Humans
- Linkage Disequilibrium
- Polymerase Chain Reaction