Article
Analysis of aberrant methylation of the VHL gene by transgenes, monochromosome transfer, and cell fusion.
Oncogene - 7 Oct 1999
Kuzmin I, Geil L, Ge H, Bengtsson U, Duh F M, Stanbridge E J, Lerman M I
Abstract excerpt
Several tumor suppressor genes were shown to be inactivated by a process involving aberrant de novo methylation of their GC-rich promoters which is usually associated with transcriptional repression. The mechanisms underlying this process are poorly understood. In particular this abnormal methylation may be caused and/or maintained by either deficiency of some trans-acting factor(s) or by various malfunctions...
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