Article
A high frequency of Y chromosome deletions in males with nonidiopathic infertility.
The Journal of clinical endocrinology and metabolism - 1 Oct 1999
Krausz C, Quintana-Murci L, Barbaux S, Siffroi J P, Rouba H, Delafontaine D, Souleyreau-Therville N, Arvis G, Antoine J M, Erdei E, Taar J P, Tar A, Jeandidier E, Plessis G, Bourgeron T, Dadoune J P, Fellous M, McElreavey K
Abstract excerpt
Microdeletions of the long arm of the human Y chromosome are associated with spermatogenic failure and have been used to define three regions of Yq (AZFa, AZFb, and AZFc) that are recurrently deleted in infertile males. In a blind study we screened 131 infertile males (46 idiopathic and 85 nonidiopathic) for Y chromosome microdeletions. Nineteen percent of idiopathic males, with an apparently normal 46,XY...
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