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Article

RET Cys634Arg mutation confers a more aggressive multiple endocrine neoplasia type 2A phenotype than Cys634Tyr mutation.

European journal of endocrinology - 1 Mar 2015

Valdés Nuria, Navarro Elena, Mesa Jordi, Casterás Anna, Alcázar Victoria, Lamas Cristina, Tébar Javier, Castaño Luis, Gaztambide Sonia, Forga Lluís

Abstract excerpt

OBJECTIVE: Specific germline mutations in the RET proto-oncogene are correlated with clinical features in multiple endocrine neoplasia type 2A (MEN2A); however, data are scarce regarding differences in clinical profiles dependent on the type of nucleotide and amino acid substitution at the same codon. We aimed to analyse differences in clinical risk profiles and outcomes among different amino acids encoded by...

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Identifiers

PMID: 25515555
DOI: 10.1530/EJE-14-0818

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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