Article
Genetic aspects of hepatocellular carcinogenesis.
Seminars in liver disease - 1 Jan 1999
Ozturk M
Abstract excerpt
Hepatocellular carcinoma (HCC) is linked etiologically to viruses (hepatitis B virus [HBV] and hepatitis C virus [HCV]), chemical carcinogens (i.e., aflatoxins), and other environmental and host factors causing chronic liver injury. Some hepatoblastomas may be linked to inherited gene mutations, but adult hereditary HCC appears to be rare. HCCs display gross genomic alterations, including DNA rearrangements...
Topics
- Adult
- Carcinoma, Hepatocellular
- Genes, Tumor Suppressor
- Genes, p53
- Germ-Line Mutation
- Hepacivirus
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Mutation