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Accommodation of foreign genes into the Sendai virus genome: sizes of inserted genes and viral replication

4 Aug 1999

Abstract excerpt

Sendai virus (SeV) is an enveloped virus with a negative sense genome RNA of about 15.3 kb. We previously established a system to recover an infectious virus entirely from SeV cDNA and illustrated the feasibility of using SeV as a novel expression vector. Here, we have attempted to insert a series of foreign genes into SeV of different lengths to learn how far SeV can accommodate extra genes and how the length of...

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PMID: 10456313
DOI: 10.1016/s0014-5793(99)00960-6

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