Article
Nitric oxide and renal nerve-mediated proximal tubular reabsorption in normotensive and hypertensive rats.
The American journal of physiology - 1 Oct 1999
Wu X C, Harris P J, Johns E J
Abstract excerpt
In Inactin-anesthetized Wistar rats with an intact renal innervation, intratubular nitro-L-arginine methyl ester (L-NAME, 10(-4) M) increased proximal fluid uptake (J(va), at 2.47 +/- 0.61 x 10(-4) mm(3). mm(-2). s(-1)) by 17% (P < 0.05), whereas coadministration with sodium nitroprusside (SNP, 10(-4) M) decreased J(va) by 18% (P < 0.01). Similar manipulation of NO generation was without effect in groups of...
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