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Article

Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected with Trypanosoma brucei.

The Journal of comparative neurology - 8 Nov 1999

Quan N, Mhlanga J D, Whiteside M B, McCoy A N, Kristensson K, Herkenham M

Abstract excerpt

Overproduction of proinflammatory cytokines in the brains of transgenic animals causes brain pathology. To investigate the relationship between brain cytokines and pathology in the brains of animals with adult-onset, pathophysiologically induced brain cytokine expression, we studied rats infected with the parasite Trypanosoma brucei. Several weeks after infection, in situ hybridization histochemistry showed a...

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PMID: 10494082
DOI: 10.1002/(sici)1096-9861(19991108)414:1<114::aid-cne9>3.0.co;2-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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