Article
TP53 mutation and haplotype analysis of two large African American families.
Human mutation - 1 Jan 1999
Hung J, Mims B, Lozano G, Strong L, Harvey C, Chen T T, Stastny V, Tomlinson G
Abstract excerpt
Two large apparently unrelated African American families with a high incidence of breast cancer and other tumors characteristic of Li-Fraumeni breast sarcoma cancer family syndrome were studied. Mutation screening revealed that in both families the affected members carried a germline mutation of the TP53 gene at codon 133 (ATG--> ACG, M133T). In order to determine whether an ancestral haplotype was shared by...
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