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Article

Norfloxacin-induced DNA cleavage occurs at the dif resolvase locus in Escherichia coli and is the result of interaction with topoisomerase IV.

Molecular microbiology - 1 Sept 1999

Hojgaard A, Szerlong H, Tabor C, Kuempel P

Abstract excerpt

The dif locus is a site-specific recombination site located within the terminus region of the chromosome of Escherichia coli. Recombination at dif resolves circular dimer chromosomes to monomers, and this recombination requires the XerC, XerD and FtsK proteins, as well as cell division. In order to characterize other enzymes that interact at dif, we tested whether quinolone-induced cleavage occurs at this site....

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Source

Identifiers

PMID: 10476036
DOI: 10.1046/j.1365-2958.1999.01545.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Norfloxacin-induced DNA cleavage occurs at the dif resolvase locus in Escherichia coli and is the result of interaction with topoisomerase IV.PMID 10476036Read ↗

The dif resolvase locus of the Escherichia coli chromosome can be replaced by a 33-bp sequence, but function depends on location.Semantic proximity Read ↗

Binding and cleavage of nicked substrates by site-specific recombinases XerC and XerD.Semantic proximity Read ↗

Escherichia coli XerC recombinase is required for chromosomal segregation at cell division.Semantic proximity Read ↗

In vitro site-specific recombination mediated by the tyrosine recombinase XerA of Thermoplasma acidophilum.Semantic proximity Read ↗

The dif/Xer recombination systems in proteobacteria.Semantic proximity Read ↗

Sister chromatid exchange frequencies in Escherichia coli analyzed by recombination at the dif resolvase site.Semantic proximity Read ↗

dif, a recA-independent recombination site in the terminus region of the chromosome of Escherichia coli.Semantic proximity Read ↗

DNA degradation in the terminus region of resolvase mutants of Escherichia coli, and suppression of this degradation and the Dif phenotype by recD.Semantic proximity Read ↗

XerCD-mediated site-specific recombination leads to loss of the 57-kilobase gonococcal genetic island.Semantic proximity Read ↗

Cell division, guillotining of dimer chromosomes and SOS induction in resolution mutants (dif, xerC and xerD) of Escherichia coli.Semantic proximity Read ↗

FtsK-dependent and -independent pathways of Xer site-specific recombination.Semantic proximity Read ↗

Site-specific recombination in the replication terminus region of Escherichia coli: functional replacement of dif.Semantic proximity Read ↗

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