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Article

MDM2 chaperones the p53 tumor suppressor.

The Journal of biological chemistry - 9 Nov 2007

Wawrzynow Bartosz, Zylicz Alicja, Wallace Maura, Hupp Ted, Zylicz Maciej

Abstract excerpt

The murine double minute (mdm2) gene encodes an E3 ubiquitin ligase that plays a key role in the degradation of p53 tumor suppressor protein. Nevertheless recent data highlight other p53-independent functions of MDM2. Given that MDM2 protein binds ATP, can interact with the Hsp90 chaperone, plays...

Read the complete abstract on PubMed

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Share to Adenosine Triphosphate
Share to Cell Line, Tumor
Share to HSP90 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

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Share to Protein Folding

Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 17848574
DOI: 10.1074/jbc.M702767200

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17848574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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