Article
Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe.
Current genetics - 1 Jul 1999
Hilti N, Baumann D, Schweingruber A M, Bigler P, Schweingruber M E
Abstract excerpt
It has been shown previously that amiloride, a widely used diuretic drug, inhibits growth in Schizosaccharomyces pombe. Here we show that the drug also alleviates repression by various nutrients of mating and sporulation in fission yeast. We selected spontaneous mutants that are amiloride-resistant and unable to mate and sporulate. One of them defines the gene ste20. This gene has been cloned and sequenced. It...
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