Article
Localization of a unique hepatitis B virus epitope sheds new light on the structure of hepatitis B virus surface antigen.
The Journal of general virology - 1 Aug 1999
Paulij W P, de Wit P L M, Sünnen C M G, van Roosmalen M H, Petersen-van Ettekoven A, Cooreman M P, Heijtink R A
Abstract excerpt
In a search for monoclonal antibodies (MAbs) that can bind hepatitis B virus surface antigen (HBsAg) with amino acid substitutions in the immune dominant 'a' region (escape mutants) we investigated the epitope recognition site of the human MAb 4-7B. Pepscan analysis and experiments with alanine substitution as well as substitutions known from nature pointed to residues 178-186 in the small S protein with the...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Epitope Mapping
- Epitopes, B-Lymphocyte
- Genetic Variation
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans