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Article

Manganese cations increase the mutation rate of human immunodeficiency virus type 1 ex vivo

1 Aug 1999

Abstract excerpt

Human immunodeficiency virus (HIV) reverse transcription is an error-prone process with an overall mutation rate of approximately 3.4 x 10(-5) per base per replication cycle. This rate can be modulated by changes in different components of the retrotranscription reaction. In particular, in vitro substitution of magnesium cations (Mg2+) by manganese cations (Mn2+) has been shown to increase misincorporation of...

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PMID: 10466794
DOI: 10.1099/0022-1317-80-8-1983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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