Article
Mutation testing of early-onset breast cancer genes BRCA1 and BRCA2.
Genetic testing - 1 Jan 1997
Neuhausen S L, Ostrander E A
Abstract excerpt
BRCA1 and BRCA2, genes predisposing to early-onset breast cancer, have been isolated and are characterized for mutation spectrum, risks of cancer, and function. The different methodologies to screen for mutations in BRCA1 and BRCA2 are briefly discussed including DNA-based methodologies and poten...
Topics
- Age of Onset
- BRCA2 Protein
- Breast Neoplasms
- DNA Mutational Analysis
- Ethnicity
- Female
- Founder Effect
- Genes, BRCA1
- Genes, Tumor Suppressor
- Genetic Testing
- Humans
- Mutation
- Neoplasm Proteins