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Article

Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences

1 Sept 1999

Abstract excerpt

The signal transduction and activator of transcription (Stat) gene family has been highly conserved throughout evolution. Gene duplication and divergence has produced 7 mammalian Stat genes, each of which mediates a distinct process. While some Stat proteins are activated by multiple cytokines, Stat2 is highly specific for responses to type I interferon. We have cloned mouse Stat2 and found that while its...

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PMID: 10464260
DOI: 10.1074/jbc.274.36.25343

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