Article
Mutations in the Ca2+ binding site of the Paracoccus denitrificans cytochrome c oxidase.
FEBS letters - 13 Aug 1999
Pfitzner U, Kirichenko A, Konstantinov A A, Mertens M, Wittershagen A, Kolbesen B O, Steffens G C, Harrenga A, Michel H, Ludwig B
Abstract excerpt
Recent structure determinations suggested a new binding site for a non-redox active metal ion in subunit I of cytochrome c oxidase both of mitochondrial and of bacterial origin. We analyzed the relevant metal composition of the bovine and the Paracoccus denitrificans enzyme and of bacterial site-directed mutants in several residues presumably liganding this ion. Unlike the mitochondrial enzyme where a low,...
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