Article
The Wilms tumour gene, WT1, in normal and abnormal nephrogenesis.
Pediatric nephrology (Berlin, Germany) - 1 Sept 1999
Pritchard-Jones K
Abstract excerpt
The Wilms tumour gene, WT1, has been shown to play an important role in normal development of the kidney and gonad. Constitutional mutations predispose to both malformation and childhood tumours of these organs. There is a genotype-phenotype correlation, with missense mutations producing more severe abnormalities than complete absence of one allele. Two syndromes with early-onset protein-losing nephropathy can be...
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